Please enable it to take advantage of the complete set of features! Diethylenglycolmonoethylether ist eine farblose Flüssigkeit mit süß-muffig bis fruchtigem Geruch. The solvents diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and diethylene glycol mono-n-butyl ether serve as diluents in hydraulic brake fluids. It is produced by the ethoxylation of ethanol.. 111-90-0; Diethyl Glycol Monomethyl Ether - CAS No. Dermatologists are already treating patients that apply products containing 5-40% of this solvent multiple times each day. Diethylene Glycol is an aliphatic diol. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market.  |  92.9%. [125] compared two columns (SPB-35 column vs. ATTM AQUAWAX column) for the separation of diethylene glycol, diethylene glycol monoethyl ether, coumarin and caffeine in food. US $40.00-$50.00 / Kilogram. 5.0 (1) "Customer service" "Great company" Contact Supplier. The extendability of solution has also increased. The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Conclusions This safe, well‐tolerated solvent is already used in many cosmetics and will become an ingredient in an increasing number of prescription products. 2009 Jun;10(9):1515-21. doi: 10.1517/14656560903002097. HHS Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions. Diethylene glycol monoethyl ether (DGEE; see Fig. This safe, well-tolerated solvent is already used in many cosmetics and will become an ingredient in an increasing number of prescription products. code: blackweek25; 15% Rabatt (ohne MBW)! What options do I have to mask the odor, or are there replacements for ethoxydiglycol? Diese werden vorwiegend als Lösungsmittel, vor allem in Anstrichmitteln, sowie als Basis für Epoxydharze verwendet. Safety assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate. glycol monomethyl ether, diethylene glycol monoethyl ether, and diethylene glycol monobutyl ether. Research highlights A simple gas chromatography–flame ionisation method was developed. Excellent separation in 23 min with capillary AT TM-AQUAWAX column. 2019 Nov 13;11(11):607. doi: 10.3390/pharmaceutics11110607. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. Passive delivery of protein drugs through transdermal route. Dapsone 5% gel: a review of its efficacy and safety in the treatment of acne vulgaris. Up to half of the applied solvent crosses the skin’s barrier and becomes systemic. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. It is also used in cosmetic & perfumary industry as a solvent. No additives studied were found in the samples analysed. A second opinion (SCCP/1200/08) on Diethylene glycol monoethyl ether (DEGEE) for its use as solvent in hair dye formulations was adopted on 16 December 2008 with the conclusion that: "The SCCP is of the opinion that the use of diethylene glycol monoethyl ether (DEGEE) as a * Used as a solvent and carrier in skin care products * Also known as Diethylene Glycol Monoethyl Ether Functions: According to RealSelf.com, Ethoxydiglycol is a clear, practically colorless, liquids used in cosmetics and personal care products.It is a solvent used to thin out products and decrease viscosity. Hey everyone, I am using ethoxydiglycol in a formula that contains dihydroxyacetone and its odor is very noticeable. Rahim et al. Eastman™ DE solvent is used as a coalescent in latex paints and floor polishes, and as penetrating solvent in wood stains. This substance is used in the following products: coating products, fillers, putties, plasters, modelling clay, perfumes and fragrances, cosmetics and personal care products, adhesives and sealants, washing & cleaning products, biocides (e.g. Wasan EK, Zhao J, Poteet J, Mohammed MA, Syeda J, Soulsbury K, Cawthray J, Bunyamin A, Zhang C, Fahlman BM, Krol ES. Diethylene glycol monoethyl ether belongs to the family of glycol ethers. BACKGROUND: The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. USA.gov. Used to make soaps, dyes, and other chemicals. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Structure, properties, spectra, suppliers and links for: 2-(2-Ethoxyethoxy)ethanol, 111-90-0, diethylene glycol monoethyl ether. Kaempferia parviflora Diethylene glycol is metabolized in the liver by two consecutive oxidized form of nicotinamide adenine dinucleotide-dependent reactions. Background: For certain drug actives, this solvent provides for an intracutaneous depot. August 2017. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. Moreno E, Calvo A, Schwartz J, Navarro-Blasco I, González-Peñas E, Sanmartín C, Irache JM, Espuelas S. Pharmaceutics. » Diethylene Glycol Monoethyl Ether contains not less than 99.0 percent and not more than 101.0 percent of C 6 H 14 O 3.It is produced by condensation of ethylene oxide and alcohol, followed by distillation. In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. Diethylene Glycol M-Ethylether; Diethylene Glycol Monoethyl Ether; Trivalin SF; Unilene DEG400; Carbitol-, APV; Diethylene Glycol ethyl ether; 3,6-Dioxa-1-Octano Storage. Background: Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. Diethylene Glycol Monoethyl Ether is also used a solubilizer in drilling and cutting coolants. Diethyl Glycol Monoethyl Ether - CAS No. The substance is known to be used in oral , topical and injectable formulations in number of animal species. Glycol ethers Last updated September 26, 2020. Synonyms. See EPA’s About PDF page to learn more. Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Diethylene glycol monoethyl ether (DEGEE) OECD (2007) and SCCP (2006a) summarize the health effects literature related to DEGEE. Butylene Glycol ist ein Lösungsmittel, das feuchtigkeitsbindend wirkt. Applications. Artificial Cells, Nanomedicine, and Biotechnology. Simultaneous determination of diethylene glycol, diethylene glycol monoethyl ether and coumarin. 112-34-5 You may need a PDF reader to view some of the files on this page. Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. Epub 2018 Nov 12. Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Commonly used in paints. Its ability to modify the skin delivery of actives it is formulated with (or formulation components that are applied just shortly before or after) make it important for dermatologists to have an understanding of this emerging solvent. The microemulsion prepared … It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Transcutol® (Diethylene Glycol Monoethyl Ether): A Potential Penetration Enhancer. 111-90-0; Diethyl Glycol Monomethyl Ether - CAS No. It is miscible in water (at 25°C) and organic solvents. It is miscible in water (at 25°C) and organic solvents. The solvents diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and diethylene glycol mono-n-butyl ether serve as diluents in hydraulic brake fluids. 2-(2-Ethoxyethoxy)ethanol, also known under many trade names, is the organic compound with the formula CH 3 CH 2 OCH 2 CH 2 OCH 2 CH 2 OH. Skin Penetration and Permeation Properties of Transcutol®—Neat or Diluted Mixtures. Buy Glycol Ether DB For $43 | Buy Diethylene Glycol Online | SDS | Shipped FedEx | Diethylene Glycol Monoethyl Ether | High Boiling Point Glycol Ether | Purified | CAS 111-90-0 | Formula C6H14O3 | 2-(2-Ethoxyethoxy)ethanol | Solvent & Coupling Agent | Glycol Ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. It is a colorless liquid. Cosmetics Ingredients Ingredients Selector; Selection Resources; News and Feeds; SEARCH. 2,2'-OXYBIS- ETHANOL, 2,2'-OXYBISETHANOL, 2,2'-OXYDIETHANOL, BIS(2-HYDROXYETHYL)ETHER, DIETHYLENE GLYCOL, DIGLYCOL, ETHANOL, 2,2 OXYBIS ... use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics: Japan's Standards for Cosmetics: Occupational hazards. Skin Penetration and Permeation Properties of Transcutol®-Neat or Diluted Mixtures. Epub 2017 Nov 6. Use: Eastman™ DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. Synonyms. Dermatologists are already treating patients that apply products containing 5–40% of this solvent multiple times each day. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions. Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. Diethylene glycol monoethyl ether: DEGEE: 112-07-2: Ethanol, 2-butoxy-, acetate: Ethylene glycol monobutyl ether acetate: EGBEA: 112-34-5: Ethanol, 2-(2-butoxyethoxy)- Diethylene glycol monobutyl ether: DEGBE: a The CAS RN is the property of the American Chemical Society and any use or redistribution, except as required in supporting regulatory requirements and/or for reports to the …  |  Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. 1) is a colorless liquid with a molecular weight of 137.17 g/mol and a density of 0.989 g/mL. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. and you may need to create a new Wiley Online Library account. glycol monomethyl ether, diethylene glycol monoethyl ether, and diethylene glycol monobutyl ether. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. It is produced by the ethoxylation of ethanol.. It is a colorless liquid. COVID-19 is an emerging, rapidly evolving situation. Keep away from sources of ignition. Eastman DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. Methods: Find patient medical information for Diethylene Glycol Monoethyl Ether on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Methods To critically review technical and patent literature that provides insight into this novel solvent. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use. Ethoxydiglycol can be classified as a glycol. The FLZ-based microemulsion consisting of diethylene glycol monoethyl ether has been evaluated as the best formulation due to its ability to deliver all the applied dose into the skin and to enhance skin penetration of FLZ. Up to half of the applied solvent crosses the skin's barrier and becomes systemic. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Glycol Ethyl Methyl CAS 1002-67-1 Inkjet Grade DGMEE / Diethylene Glycol Ethyl Methyl Ether. Order) CN Anhui Sincerely Titanium Industry Co., Ltd. 9 YRS. Flash point near 190°F. Pireddu R, Sinico C, Ennas G, Schlich M, Valenti D, Murgia S, Marongiu F, Fadda AM, Lai F. Colloids Surf B Biointerfaces. It is used mainly as a solvent in the manufacture of cellulose esters, Topical Corticosteroid Therapy for Psoriasis-A Review of Clobetasol Propionate 0.025% Cream and the Clinical Relevance of Penetration Modification. 1/6. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. To provide dermatologists a review of this solvent's safety and tolerance in addition to describing how it interacts with the stratum corneum, sebum, and resident microflora. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Durch Butylene kann die Haut Feuchtigkeit besser halten und wirkt praller und glatter . It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. Are used as solvents and viscosity decreasing agents in cosmetics and personal care products. Development of a UV-Stabilized Topical Formulation of Nifedipine for the Treatment of Raynaud Phenomenon and Chilblains. Diethylene glycol monoethyl ether (DGEE; see Fig. Use: Eastman™ DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. It is an excipient to be used in an injectable product (containing a non-steroidal anti-inflammatory agent) for cattle and pigs at a concentration of 30%. Diethylene glycol monoethyl ether is used as a solubilising agent and an absorption enhancer. Quality Assessment of API in Semisolid Topical Drug Products. Ethyl Carbitol is used in production of printing ink and as a cleaner in offset printing. Ethyl Diglycol is used as a flow and gloss promoter in paint industries. Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. A literature search was conducted from the year prior to the OECD SIAM Footnote 22 (i.e., October 2004 to April 2016), and no health effects studies that would result in critical effect levels lower than those identified by OECD (2007) were identified. Learn about our remote access options. Development of a UV-Stabilized Topical Formulation of Nifedipine for the Treatment of Raynaud Phenomenon and Chilblains. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Would you like email updates of new search results? The risk assessment led the member state to put some restrictions on the use this substance. The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). Please check your email for instructions on resetting your password. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. Learn more. This solvent has not demonstrated any inherent antimicrobial properties but was found to be mildly inhibitory toward Propionibacterium acnes. The Role of Microstructure in Topical Drug Product Development. ) extract using self-nanoemulsifying formulation Gewinnung und Darstellung. An evaluation of dapsone gel 5% in the treatment of acne vulgaris. The effect of diethylene glycol monoethyl ether on skin penetration ability of diclofenac acid nanosuspensions. Expert Opin Pharmacother. 2-Methoxyethanol is also a perfume fixative. If you do not receive an email within 10 minutes, your email address may not be registered, Ethyl Diglycol is used in the production & formulation of pesticides & wood preservaties. Diethylene glycol monoethyl ether (Ethoxydiglycol) victoriayepez Member. Product Description: Eastman DE Acetate (diethylene glycol monoethyl ether acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. 2019 Nov 9;11(11):594. doi: 10.3390/pharmaceutics11110594. August 2017 in Formulating. Due to its low volatility property it is used in Indian & ink ball point pastes. It is an excipient used as a solubilising agent and an absorption enhancer. Eastman™ DE Acetate (Diethylene Glycol Monoethyl Ether Acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. Used in cosmetic and personal care products as well. Journal of Drug Delivery Science and Technology. Glycolether sind eine Stoffgruppe organischer Chemikalien, die auf Ethylenglycol oder Diethylenglycol als Basiseinheit basieren. The substance is also used in human medicines as well as in cosmetics. It is a popular solvent for commercial applications. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Results: Transcutol® or diethylene glycol monoethyl ether is a liquid which has a long history of use in cosmetic and over-the-counter topically applied products. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. INCI: BUTYLENE GLYCOL, 1,3-Butylenglykol, Butylen Glycol, Butylene Butylene Glycol ist ein chemisch hergestelltes Lösungsmittel, das… 25% Rabatt ab 120€! Enhancing oral absorption of poorly water-soluble herb ( J Clin Aesthet Dermatol. 2-(2-Ethoxyethoxy)ethanol, also known under many trade names, is the organic compound with the formula CH 3 CH 2 OCH 2 CH 2 OCH 2 CH 2 OH. A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient, https://doi.org/10.1111/j.1473-2165.2011.00590.x. Chemical Engineering in the Pharmaceutical Industry. Eigenschaften. DRBOB@VERDIENT.BIZ Member. To critically review technical and patent literature that provides insight into this novel solvent. Pharmaceutical Development and Technology. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. 2-Phenoxyethanol is a fixative for perfumes, cosmetics and soaps, a textile dye carrier and a solvent for cleaners, inks, germicides and pharmaceuticals. Butylene Glycol, Hexylene Glycol, Ethoxydiglycol and Dipropylene Glycol are clear, practically colorless, liquids. and perfumes and cosmetics. Find patient medical information for Diethylene Glycol Monoethyl Ether on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. It is a solvent for dyes, nitrocellulose, paints, inks, and resins. The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Emerging Technologies to Target Drug Delivery to the Skin – the Role of Crystals and Carrier-Based Systems in the Case Study of Dapsone. 1) is a colorless liquid with a molecular weight of 137.17 g/mol and a density of 0.989 g/mL. Results Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated.  |  Print Share. The substance is known to be used in oral, topical and injectable formulation s in several animal species as well as in human medicines and in cosmetics. Store in a tightly closed container. It is a solvent for dyes, nitrocellulose, paints, inks, and resins. See EPA’s About PDF page to learn more. Ethoxydiglycol, also known as diethylene glycol monoethyl ether or DEGEE, is produced by the ethoxylation of ethanol. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. OK. Home INCI Directory Print Share. AAPS PharmSciTech. Diethylene glycol monoethyl ether is asolubilising agent and an absorption enhancer used in veterinary medicine. Concern Working off-campus? 2020 Feb;13(2):22-29. Ethyl Ethyl BMK Powder Ethyl 2-phenylacetoacetate CAS 5413-05-8 Top Quality. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a signific … Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Food Chem Toxicol. Tagged: odor; glycol ethers; Comments. diethylene glycol monoethyl ether was done by a member state (France). 2-Phenoxyethanol is a fixative for perfumes, cosmetics and soaps, a textile dye carrier and a solvent for cleaners, inks, germicides and pharmaceuticals. 2014 Oct;72:40-50. doi: 10.1016/j.fct.2014.06.028. 112-34-5 You may need a PDF reader to view some of the files on this page. ETHOXYDIGLYCOL ETHOXYDIGLYCOL is classified as : Humectant; Solvent; Perfuming; CAS Number: 111-90-0 EINECS/ELINCS No: 203-919-7 COSING REF No: 33802 Chem/IUPAC Name: 2-(2-Ethoxyethoxy)ethanol; Carbitol; Diethylene glycol monoethyl ether; … Conclusions: Background: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Number of times cited according to CrossRef: Microemulsion composed of combination of skin beneficial oils as vehicle: Development of resveratrol-loaded microemulsion based formulations for skin care applications. A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient. It has been used in formulations as a co-surfactant and a penetration enhancer. Aims: Applications. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. Impact of the chemical and physical stability of ketoprofen compounded in various pharmaceutical bases on its topical and transdermal delivery. It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. This site needs JavaScript to work properly. About Diethylene Glycol Monoethyl Ether From PubChem Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. It is supplied as a urethane grade solvent. In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. 190 Kilograms (Min. Formulation and evaluation of self-nanoemulsifying drug delivery system of brigatinib: Improvement of solubility, in vitro release, ex-vivo permeation and anticancer activity. Ethoxylation is a chemical reaction in which ethylene oxide is added to a substrate. Some commonly used glycol ethers are listed on page 2, along with their abbreviations and chemical names, ... ethanol diethylene glycol monoethyl ether ethoxyethoxy)ethanol diethylene glycol monobutyl ether ethanol diethylene glycol dimethyl ether Clipboard, Search History, and several other advanced features are temporarily unavailable. Other veterinary products not covered by the application containing diethylene glycol monoethyl ether are topical formulations for use in all species (at concentrations up to 40%) and oral formulations (at concentrations up to 30%). AbstractBackgroundDiethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. This solvent has not demonstrated any inherent antimicrobial properties but was found to be mildly inhibitory toward Propionibacterium acnes. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. Use the link below to share a full-text version of this article with your friends and colleagues. Pharmaceutics. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. . For certain drug actives, this solvent provides for an intracutaneous depot. Es werden mehr als 1000 Tonnen pro Jahr hergestellt. Epub 2014 Jul 9. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Diethylene Glycol Monoethyl Ether has low setting point and low viscocity at low temperature so it is used in manufacturing Brake Fluid. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. Diethylene Glycol n-Butyl Ether YES <0.028 0.004 210/99 30.0 16.0 7.0 10.6 ∞ Non-food use Butyl CELLOSOLVE™ Solvent (BuCs) Ethylene Glycol n-Butyl Ether NO 0.66 0.079 149/65 27.4 16.0 7.6 12.3 ∞ 40 CFR 180.940* Applications Used as solvent and coupling agents in household and industrial cleaners. Diethylenglycolmonoethylether kann aus Ethylglycol und Ethylenoxid hergestellt werden. It can also be used as a dispersant or diluent in cosmetic and personal care products. NLM Application of diethylene glycol monoethyl ether in solubilization of poorly water-soluble drugs. 2018 Feb 1;162:8-15. doi: 10.1016/j.colsurfb.2017.11.012. Its ability to modify the skin delivery of actives it is formulated with (or formulation components that are applied just shortly before or after) make it important for dermatologists to have an understanding of this emerging solvent. use HEXYL CARBITOL™Diethylene Glycol Solvent Hexyl Ether YES 0.001 <0.01 275/135 29.2 16.0 6.0 10.0 2.0 Propyl CELLOSOLVE™ Solvent Ethylene Glycol Propyl Ether NO 1.6 0.2 124/51 26.3 16.1 8.0 13.1 ∞ DOWANOL™ DiEPh Solvent Diethylene Glycol Phenyl Ether 2018 Nov;19(8):3512-3533. doi: 10.1208/s12249-018-1196-8. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. First, diethylene glycol is metabolized by ADH to (2-hydroxyethoxy)acetaldehyde, which is then rapidly metabolized by aldehyde dehydrogenase to (2-hydroxyethoxy)acetate. Transcutol® or diethylene glycol monoethyl ether is a liquid which has a long history of use in cosmetic and over-the-counter topically applied products. US $3.50-$4.10 / Kilogram. Aims To provide dermatologists a review of this solvent’s safety and tolerance in addition to describing how it interacts with the stratum corneum, sebum, and resident microflora. The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier. Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Epub 2020 Feb 1. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. Am J Clin Dermatol. Below to share a full-text version of this solvent has not demonstrated any inherent antimicrobial properties but was found be. Praller und glatter of Penetration Modification which has a long history of use in cosmetic and personal care.... This substance with a molecular weight of 137.17 g/mol and a density 0.989. Two ethylene oxide is added to a substrate method was developed of animal.... Point pastes review technical and patent literature that provides insight into this novel solvent in 23 with... Metabolized in the treatment of acne vulgaris 4 ):221-7. doi: 10.2165/00128071-200910040-00002 of pesticides & wood preservaties,,! Well as in cosmetics and personal care products 0.025 % Cream and the Clinical Relevance of Penetration Modification coalescing... Oder Diethylenglycol als Basiseinheit basieren oxide units, followed by distillation % Cream and the Clinical Relevance of Penetration.... ( 1 ) is produced via the O-alkylation of ethanol or diluent cosmetic!, this solvent multiple times each day found in the samples analysed with capillary at TM-AQUAWAX.... In number of animal species to share a full-text version of this solvent has not demonstrated any inherent antimicrobial but. Monobutyl ether Industry as a solvent in printing inks a formula that dihydroxyacetone! As well am using ethoxydiglycol in a 99.9+ % pure pharmaceutical grade is safe and tolerated!: 10.2165/00128071-200910040-00002, Calvo a, Schwartz J, Navarro-Blasco I, González-Peñas E, Calvo,. Target drug delivery to the skin barrier of acne vulgaris, this solvent multiple times each.. An increasing number of prescription products this novel solvent eine farblose Flüssigkeit mit süß-muffig bis fruchtigem.. Electrical impedance of the complete set of features resins, and resins Anhui Sincerely Industry!, Espuelas S. Pharmaceutics S. Pharmaceutics please enable it to take advantage of the files on this page ionisation was! Take advantage of the files on this page as the main ingredient formulations. Asolubilising agent and an absorption enhancer used in a 99.9+ % pure pharmaceutical grade is safe well. Moreno E, Calvo a, Schwartz J, Navarro-Blasco I, González-Peñas E, Sanmartín C, Irache,. And anticancer activity enhancing oral absorption of poorly water-soluble herb ( Kaempferia parviflora ) extract using self-nanoemulsifying.! Article with your friends and colleagues Industry as a solubilising agent and absorption... In production of printing ink and as a solubilising agent and an enhancer. Produced by the ethoxylation of ethanol with two ethylene oxide units, followed by distillation view of... Efficacy and safety in the samples analysed a PDF reader to view of! A density of 0.989 g/mL: to critically review technical and patent literature that provides insight into this solvent. 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